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| Reactivity: | R & R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | MRP1 rabbit polyclonal |
Gene Name: | Multidrug resistance-associated protein 1 |
Synonyms: | ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter, Abcc1, Mrp1, LTC4 transporter |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse MRP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 800-1: 1600 | lymphoid, brain |
IF | Rat | 1: 400-1: 800 | lymphoid, brain |
Background
MRP1 is a member of the MRP subfamily of ATPbindingcassette (ABC) transporters . MRP1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agent sand the glutathione (GSH) conjugates of these compounds. MRP1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids,leukotrienes and prostaglandins. Although MRP1 is generally expressed in normaltissue, upregulation of MRP1 has been found in avariety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer . Research studies show that over expression of MRP1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients. Research studies also show that elevated expression of MRP1 is a negative prognostic marker for breast cancer and small cell lung cancer, as the level of MRP1 is predictive of the response and toxicity of chemotherapeutic agents in those patients.
Images
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Immunohistochemistry analysis of paraffin-embedded rat lymphoid usingMRP1 (GB111041) at dilution of 1: 1600 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using MRP1 (GB111041) at dilution of 1: 1600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
