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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Mdm2-binding protein |
Synonyms: | hMTBP, Mdm2 binding protein, MDM2BP, MTBP |
Immunogen: | Recombinant protein corresponding to Mouse MTBP |
Uniprot ID: | Q8BJS8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Product Usage Information
IHC/IF | Human | 1: 1000-1: 2000 | kidney, lung cancer, colon cancer |
Background
May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells.
Images
| Immunohistochemistry analysis of paraffin embedded human kidney using MTBP (GB114421) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human lung cancer using MTBP (GB114421) at dilution of 1: 1000 |
| Immunofluorescence analysis of paraffin embedded human colon cancer using MTBP (GB114421) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
