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| Reactivity: | R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Mark3 rabbit polyclonal antibody |
Gene Name: | MAP/microtubule affinity-regulating kinase 3 |
Synonyms: | cTAK1, Cdc25C-associated protein kinase 1, ELKL motif kinase 2, EMK-2, Protein kinase STK10, Ser/Thr protein kinase PAR-1, Par-1a, Serine/threonine-protein kinase p78, Mark3, EMK2/MARK3 serine-threonine protein kinase, MPK-10, serine/threonine kinase 10 |
Immunogen: | Recombinant protein corresponding to Human Mark3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 84 kDa |
Observed MW. | 84 kDa |
Uniprot ID: | Q8VHF0 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Rat | 1: 500-1: 1000 | lung, kidney, stomach |
Background
Serine/threonine-protein kinase . Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU . Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus . Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.
Images
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Western blot analysis of ctak1 (GB11976) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
