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Anti-NADPH oxidase 4 Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NADPH oxidase 4 rabbit polyclonal antibody |
Gene Name: | NADPH oxidase 4 |
Synonyms: | NOX4, KOX, KOX-1, RENOX, NADPH oxidase 4 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NOX4 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum membrane, Cell membrane, Cell junction |
Predicted MW. | 70 kDa |
Observed MW. | 70 kDa |
Uniprot ID: | Q9JHI8, Q9NPH5, Q924V1 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Rat | 1:1000-1:2000 | skeletal muscle, lung, kidney |
IHC/IF | Human, Mouse, Rat | 1:1000-1:2000 | brain, spleen |
Background
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. Nox4 protects the vasculature against inflammatory stress.Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.
Images
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Western blot analysis of NOX4 (GB11347) at dilution of 1: 1000 |
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Immunofluorescence of paraffin embedded mouse brain using NOX4 (GB11347) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat spleen using NOX4 (GB11347) at dilution of 1: 1000 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse cerebellum using NOX4 (GB11347) at dilution of 1: 2000 |
| Immunohistochemistry of paraffin embedded rat cerebellum using NOX4 (GB11347) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
