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Anti-NANOS2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Nanos homolog 2 |
Synonyms: | NOS2, ZC2HC12B |
Immunogen: | Recombinant protein corresponding to Mouse NANOS2 |
Uniprot ID: | P60322 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Product Usage Information
IHC/IF | Mouse, Rat | 1: 600-1: 1200 | testis |
Background
Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state.
Images
| Immunohistochemistry analysis of paraffin embedded mouse testis using NANOS2 (GB114466) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded rat testis using NANOS2 (GB114466) at dilution of 1: 600 |
| Immunofluorescence analysis of paraffin embedded mouse testis using NANOS2 (GB114466) at dilution of 1: 600 |
| Immunofluorescence analysis of paraffin embedded rat testis using NANOS2 (GB114466) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
