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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NEAS rabbit polyclonal antibody |
Gene Name: | Spectrin alpha chain, non-erythrocytic 1 |
Synonyms: | Alpha-II spectrin, Alpha Fodrin, SPTAN1, EIEE5, NEAS, SPTA2, spectrin alpha, Non-erythrocytic 1, Non-erythroid alpha chain |
Immunogen: | Recombinant protein corresponding to Mouse NEAS |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 290 kDa |
Observed MW. | 285 kDa |
Uniprot ID: | Q13813, P16546, P16086 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | muscle, lung, stomach |
Background
The spectrins are a family of widely distributed cytoskeletal proteins which are involved in actin crosslinking, cell adhesion, intercellular communication and cell cycle regulation. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Though a role in cardiac muscle is not well understood, it is likely that alpha II-spectrin is involved in organizing sub-sarcolemmal domains and stabilizing sarcolemmal membranes against the stresses associated with continuous cardiac contraction.
Images
 |
Western blot analysis of α-Fodrin (GB11579) at dilution of 1: 500 |
Storage
| Storage |
Store at -20°C for one year. Avoid repeated freeze/thaw cycles |
| Storage Buffer |
PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol. |
