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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NLK rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase NLK |
Synonyms: | Nlk, NLK, nemo like kinase |
Immunogen: | Recombinant protein corresponding to Mouse NLK |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 4000 | corpus striatum, fetal brain, lung, spinal cord |
Background
Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.
Images
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Immunohistochemistry of paraffin embedded mouse lung using NLK (GB11904) at dilution of 1:2000 (250x lens) |
 | Immunohistochemistry of paraffin embedded rat corpus striatum using NLK (GB11904) at dilution of 1:2000 (200x lens) |
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Immunohistochemistry of paraffin embedded rat lung using NLK (GB11904) at dilution of 1:2000 (250x lens) |
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Immunohistochemistry of paraffin embedded rat spinal cord using NLK (GB11904) at dilution of 1:2000 (250x lens) |
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Immunohistochemistry analysis of paraffin-embedded rat heart using NLK (GB11904) at dilution of 1: 1000 |
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Immunofluorescence of paraffin embedded rat corpus striatum using NLK (GB11904) at dilution of 1:1500 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
