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Anti-NOTCH3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | NOTCH3 rabbit polyclonal antibody |
Gene Name: | Neurogenic locus notch homolog protein 3 |
Synonyms: | Notch 3, NOTCH3, Notch 3 extracellular truncation, Notch 3 intracellular domain, CADASIL, CASIL |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NOTCH3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 244 kDa |
Observed MW. | 110 kDa (cleaved) |
Uniprot ID: | Q9UM47 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 100-1: 500 | HeLa, MCF-7, K562 |
Background
NOTCH3 belongs to the NOTCH family. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Images
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Western blot analysis of Notch3 (GB111310) at dilution of 1: 100 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
