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| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | NPC intracellular cholesterol transporter 1 |
Synonyms: | Niemann Pick C1 protein, Niemann Pick disease, type C1, NPC1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse NPC1 |
Uniprot ID: | O35604 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 143 kDa / 150 kDa |
Product Usage Information
WB | Mouse | 1: 300-1: 600 | L-929 |
Background
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment . Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket . May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
Images
| Western blot analysis of NPC1 (GB114642) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
