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Anti-Nanos3 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Nanos3 rabbit polyclonal antibody |
Gene Name: | Nanos homolog 3 |
Synonyms: | NOS-3, Nanos3, Nos3, Nanos C2HC-Type Zinc Finger 3, ZC2HC12C, NANOS1L |
Immunogen: | Recombinantproteincorrespondingto Mouse Nanos3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 19 kDa |
Observed MW. | 19 kDa |
Uniprot ID: | P60324 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 500-1: 1000 | testis, kidney, brain |
Background
Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2-null primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3-null PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3-null background. Nanos3 expression can not rescue Nanos2-null defects.
Images
 | Western blot analysis of Nanos3 (GB111666) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
