Your shopping cart is empty!
Anti-Nesprin3 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Nesprin3 rabbit polyclonal |
Gene Name: | Nesprin-3 |
Synonyms: | KASH domain-containing protein 3, KASH3, Nuclear envelope spectrin repeat protein 3, Syne3, C14orf49, Spectrin Repeat Containing, Nuclear Envelope Family Member 3, Nesp3, Chromosome 14 open reading frame 49, NET53 |
Immunogen: | Recombinant protein corresponding to Mouse Nesprin3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 112 kDa |
Observed MW. | 112 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 300-1: 800 | testis, spleen |
Background
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
Images
 | Western blot analysis of Nesprin3 (GB113442) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
