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Anti-Nicotinic Acetylcholine Receptor beta/CHRNB1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Nicotinic Acetylcholine Receptor beta/CHRNB1 rabbit polyclonal |
Gene Name: | Acetylcholine receptor subunit beta |
Synonyms: | ACHRB, CHRNB, CHRNB1, CMS1D, CMS2A, SCCMS, Nicotinic acetylcholine receptor beta subunit precursor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Nicotinic Acetylcholine Receptor beta/CHRNB1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1000-1: 2000 | cerebellum |
Background
Acetylcholine receptors (AChRs) are integral membrane proteins that respond to the binding of acetylcholine (ACh), a neurotransmitter synthesized, stored and finally released by cholinergic neurons. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) subunits. CHRNB1 gene encodes acetylcholine receptor subunit beta (ACHRB). Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using Chrnb1 (GB113337) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded rat cerebellum using Chrnb1 (GB113337) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
