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Anti-Nrros Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Transforming growth factor beta activator LRRC33 |
Synonyms: | Nrros, Lrrc33, Leucine-rich repeat-containing protein 33, Negative regulator of reactive oxygen species |
Immunogen: | Recombinant protein corresponding to Mouse Nrros |
Uniprot ID: | Q8BMT4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 77 kDa / 77 kDa |
Product Usage Information
WB | Human | 1: 300-1: 600 | HCT 116 |
Background
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system . Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 . TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS .
Images
| Western blot analysis of NRROS (GB114588) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
