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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | OPA1 rabbit polyclonal antibody |
Gene Name: | Dynamin-like 120 kDa protein |
Synonyms: | Large GTP-binding protein, LargeG, Optic atrophy protein 1 homolog, Opa1, Juvenile kjer type optic atrophy, MGM1, NPG |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse OPA1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 111 kDa |
Observed MW. | 90 kDa |
Uniprot ID: | O60313, P58281, Q2TA68 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | liver, kidney |
Background
OPA1 is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. OPA1 localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. OPA1 is associated with the inner membrane and protects cells from apoptosis by regulating inner membrane dynamics. Mutation of OPA1 causes the disease dominant optic atrophy, a degeneration of the retinal ganglion cells. OPA1 undergoes complex posttranscriptional regulation and posttranslational proteolysis. OPA1 is regulated by proteolytic cleavage, which degrades long OPA1 isoforms into short isoforms. The gene OPA1 can be cleaved into some chains with MW 100 kDa and 80-90 kDa.
Images
| Western blot analysis of OPA1 (GB111728) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
