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Anti-OTUB1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | OTUB1 rabbit polyclonal |
Gene Name: | Ubiquitin thioesterase OTUB1 |
Synonyms: | Deubiquitinating enzyme OTUB1, hOTU1, OTB1, OTU1, Otub1, Otubain 1, Ubiquitin specific processing protease OTUB1, Ubiquitin-specific-processing protease OTUB1 |
Immunogen: | Recombinant protein corresponding to Mouse OTUB1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 31 kDa |
Observed MW. | 34 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | brain, kidney, liver, heart |
Background
OTUB1 is a 271 amino acid protein that contains one OTU (ovarian tumor) domain and belongs to the OTU family of predicted cysteine proteases. Expressed as two isoforms (one of which is present throughout the body and the other of which is present only in lymphoid tissues), OTUB1 functions as a hydrolase that can remove ubiquitin residues from target proteins, thereby preventing protein degradation and playing an important role in protein turnover. OTUB1 interacts with GRAIL and, via this interaction, plays a role in the regulation and the induction of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to their cognate antigens. Due to its interaction with GRAIL, OTUB1 is an important regulator of immune responses in secondary lymphoid organs.
Images
 | Western blot analysis of OTUB1 (GB113129) at dilution of 1: 2000 |
| Western blot analysis of OTUB1 (GB113129) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
