Your shopping cart is empty!
Anti-P2Y12 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | P2Y12 rabbit polyclonal antibody |
Gene Name: | P2Y purinoceptor 12 |
Synonyms: | ADP glucose receptor, ADPG-R, Purinergic receptor P2RY12, Platelet ADP receptor, HORK3, BDPLT8, P2Y12, P2ry12 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse P2Y12 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 39 kDa |
Observed MW. | 50 kDa |
Uniprot ID: | Q9CPV9 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 250-1: 500 | kidney, brain |
IHC/IF | Mouse, Rat | 1: 1000-1: 3000 | brain, spinal cord |
Background
The P2Y receptor family are G protein-coupled receptors which mediate the effects of extracellular nucleotides, primarily through the activation of phospholipase C. To some extent, the P2Y receptors can also activate potassium channels or, alternatively, inhibit adenylate cyclase and N-type calcium channels in response to extracellular nucleotides. Human platelets express two G protein-coupled nucleotide receptors, P2Y1 and P2Y12. P2Y12 is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. P2Y12 is an integral membrane protein involved in platelet aggregation.
Images
| Western blot analysis of P2Y12 (GB112164) at dilution of 1: 250 |
| Immunohistochemistry of paraffin embedded mouse brain using P2Y12 (GB112164) at dilution of 1: 1400 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse spinal cord using P2Y12 (GB112164) at dilution of 1: 1400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
