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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PAK2 rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein kinase PAK 2 |
Synonyms: | Gamma-PAK, C t PAK2, p21 activated kinase 2, p27 PAK 2p34, p34, p58, PAK 2, PAK2, PAK65, PAKgamma, S6/H4 kinase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PAK2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Membrane, Nucleus |
Uniprot ID: | Q8CIN4, Q64303 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 400-1: 1000 | brain, heart, skeletal muscle |
Background
PAK2, also named as PAK65, PAKgamma, p58, PAK-2p27, PAK-2p24 and C-t-PAK2, belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. PAK2 has several isoforms with the MW of 54-62 kDa and 41 kDa. The 62 kDa PAK2 is cleaved into a 34 kDa C terminal fragment and a 28 kDa N terminal fragment with a time course that parallels apoptotic death in Jurkat cells.
Images
| Immunohistochemistry of paraffin embedded mouse heart using PAK2 (GB111966) at dilution of 1:600 (400x lens) |
| Immunohistochemistry of paraffin embedded rat heart using PAK2 (GB111966) at dilution of 1:600 (300x lens) |
| Immunohistochemistry of paraffin embedded rat brain using PAK2 (GB111966) at dilution of 1:600 (400x lens) |
| Immunofluorescence of paraffin embedded mouse heart using PAK2 (GB111966) at dilution of 1:400 (400x lens) |
| Immunofluorescence of paraffin embedded mouse Skeletal muscle using PAK2 (GB111966) at dilution of 1:600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
