Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PAR4 rabbit polyclonal antibody |
Gene Name: | PRKC apoptosis WT1 regulator protein |
Synonyms: | Prostate apoptosis response 4 protein, Par-4, Pawr, Par4, WT1 Interacting Protein, Transcriptional repressor Par-4-like protein PAWR, PRKC Apoptosis WT1 Regulator |
Immunogen: | Recombinant protein corresponding to Mouse PAR4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 36 kDa |
Observed MW. | 41 kDa |
Uniprot ID: | Q96IZ0, Q925B0, Q62627 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | pancreas |
Background
PAWR, also named as PAR4, is a pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. It induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. PAWR inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. It down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. PAWR may be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Images
| Western blot analysis of PAWR (GB111913) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
