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Anti-PARK7/DJ1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Protein/nucleic acid deglycase DJ-1 |
Synonyms: | PARK7, DJ-1, DJ1, HEL-S-67p, Parkinsonism associated deglycase, GATD2 |
Immunogen: | Recombinant protein corresponding to Mouse PARK7 |
Uniprot ID: | Q99LX0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane, Mitochondrion, Nucleus |
Predicted MW. / Observed MW. | 20 kDa / 24 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, liver, kidney, brain |
IHC/IF | Rat | 1: 500-1: 3000 | pancreas |
Background
Protein deglycase DJ-1, also known as Parkinson disease protein 7, is a protein which in humans is encoded by the PARK7 gene. Under an oxidative condition, protein deglycase DJ-1 inhibits the aggregation of α-synuclein via its chaperone activity, thus functions as a redox-sensitive chaperone and as a sensor for oxidative stress. Accordingly, DJ-1 apparently protects neurons against oxidative stress and cell death. In parallel, Protein DJ-1 acts as a positive regulator of androgen receptor-dependent transcription.
Images
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Western blot analysis of PARK7 (GB11639) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin embedded rat pancreas using Cap (GB11639) at dilution of 1: 3000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
