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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PAX6 rabbit polyclonal antibody |
Gene Name: | Paired box protein Pax-6 |
Synonyms: | Pax6, PAX6, AN, AN2, D11S812E, FVH1, MGDA, WAGR, paired box 6, ASGD5 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PAX6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P63015, P63016 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 4000 | eye |
Background
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
Images
 | Immunohistochemistry of paraffin embedded mouse eye using PAX6 (GB11777) at dilution of 1:2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat eye using PAX6 (GB11777) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse eye using PAX6 (GB11777) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
