Your shopping cart is empty!
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PCB rabbit polyclonal |
Gene Name: | Pyruvate carboxylase, mitochondrial |
Synonyms: | Pyruvic carboxylase, PCB, Pc, Pcx, pyruvate Carboxylase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PCB |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 130 kDa |
Observed MW. | 130 kDa |
Uniprot ID: | P11498, Q05920 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | fat, brain |
Background
PC(pyruvate carboxylase) is a member of the family of biotin-dependent carboxylases and is found widely among eukaryotic tissues and in many prokaryotic species. It catalyses the ATP-dependent carboxylation of pyruvate to form oxaloacetate which may be utilised in the synthesis of glucose, fat, some amino acids or their derivatives and several neurotransmitters. Diabetes and hyperthyroidism increase the level of expression of pyruvate carboxylase in the long term, while its activity in the short term is controlled by the intramitochondrial concentrations of acetyl-CoA and pyruvate.
Images
 | Western blot analysis of PCB (GB113002) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
