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Anti-PCGF1 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PCGF1 rabbit polyclonal antibody |
Gene Name: | Polycomb group RING finger protein 1 |
Synonyms: | Nervous system Polycomb-1, NSPc1, RING finger protein 68, Pcgf1, Nspc1, Rnf68 |
Immunogen: | Recombinant protein corresponding to Mouse PCGF1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | Q8R023, Q6DLV9 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 600-1: 3000 | testis |
Background
PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.
Images
| Immunohistochemistry of paraffin embedded mouse testis using PCGF1 (GB112278) at dilution of 1:700 (300x lens) |
| Immunohistochemistry of paraffin embedded rat testis using PCGF1 (GB112278) at dilution of 1:700 (300x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
