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Anti-PDE12 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | 2',5'-phosphodiesterase 12 |
Synonyms: | 2 PDE, 2' PDE, 2,5 phosphodiesterase 12, PDE12, phosphodiesterase 12 |
Immunogen: | Recombinant protein corresponding to Mouse PDE12 |
Uniprot ID: | Q3TIU4 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 68 kDa / 68 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | heart, liver |
Background
Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells.
Images
| Western blot analysis of PDE12 (GB114485) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
