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Anti-PGP9.5 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ubiquitin carboxyl-terminal hydrolase isozyme L1 |
Synonyms: | UCH-L1, Neuron cytoplasmic protein 9.5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1, Uchl1, PARK5, Uch-L1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PGP9.5 |
Uniprot ID: | Q9R0P9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Endoplasmic reticulum membrane |
Predicted MW. / Observed MW. | 27 kDa / 27 kDa |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, cerebellum, spinal marrow |
IHC | Mouse, Rat | 1: 1000-1: 2000 | brain |
IF | Mouse, Rat | 1: 1000-1: 2000 | brain |
Background
UCHL1(Ubiquitin carboxyl-terminal hydrolase isozyme L1) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons. This protein is present in brain at concentrations at least 50 times greater than in other organs and is a major protein component of neuronal cytoplasm . And UCHL1 is a Parkinson's disease susceptibility gene.
Images
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Western blot analysis of PGP9.5 (GB11159-1) at dilution of 1:600. Lane 1: Mouse brain tissue lysate Lane 2: Mouse cerebellum tissue lysate Lane 3: Mouse cerebral cortex tissue lysate Lane 4: Rat brain tissue lysate Lane 5: Rat cerebellum tissue lysate Lane 6: Rat cerebral cortex tissue lysate |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using PGP9.5 (GB11159-1) at dilution of 1:1000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using PGP9.5 (GB11159-1) at dilution of 1:1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
