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Anti-PICALM Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Phosphatidylinositol-binding clathrin assembly protein |
Synonyms: | Clathrin assembly lymphoid myeloid leukemia, Calm, Fit1, LAP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PICALM |
Uniprot ID: | Q7M6Y3 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 72 kDa / 68 kDa |
Product Usage Information
WB | Human, Mouse | 1: 2000-1: 4000 | lung |
Background
Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8.
Images
| Western blot analysis of PICALM (GB114822) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
