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Anti-PI 3 Kinase catalytic subunit alpha/PIK3CA Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PIK3CA rabbit polyclonal antibody |
Gene Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
Synonyms: | PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, CLAPO |
Immunogen: | Recombinant protein corresponding to Mouse PIK3CA |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cell membrane |
Uniprot ID: | P42337 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | brain, liver cancer |
Background
PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdInsP2. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit.
Images
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Immunohistochemistry of paraffin embedded mouse brain using P110α (GB11769) at dilution of 1:2000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using P110α (GB11769) at dilution of 1:2000 (400x lens) |
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Immunofluorescence of paraffin embedded human liver cancer using P110α (GB11769) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
