Your shopping cart is empty!
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Serine/threonine-protein kinase pim-3 |
Synonyms: | Pim3, pim-3 |
Immunogen: | Recombinant protein corresponding to Mouse PIM3 |
Uniprot ID: | P58750 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 36 kDa / 38 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 800 | skeletal muscle, brain |
Background
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
Images
| Western blot analysis of PIM3 (GB114375) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
