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Anti-PINK1 Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Serine/threonine-protein kinase PINK1, mitochondrial |
Synonyms: | BRPK, PARK6, PINK1, PTEN induced putative kinase 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human PINK1 |
Uniprot ID: | Q9BXM7 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Mitochondrion |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 600 | Heart, skeletal muscle |
IHC/IF | Human, Mouse, Rat | 1: 200-1: 400 | heart, liver cancer, bladder cancer |
Background
PINK1 is a mitochondrial serine/threonine-protein kinase that protects cells from stress-induced mitochondrial dysfunction. The precursor of PINK1 (65 kDa) is synthesized in the cytosol and is imported into the outer membrane of mitochondria. PINK1 is further transferred into the inner membrane. The full-length PINK1 can be proteolytically processed into 52-55 kDa and 45-46 kDa forms.
Images
| Western blot analysis of PINK1 (GB114934) at dilution of 1: 600 |
| Immunohistochemistry analysis of paraffin embedded mouse heart using PINK1 (GB114934) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded rat heart using PINK1 (GB114934) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded human liver cancer using PINK1 (GB114934) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded human bladder cancer using PINK1 (GB114934) at dilution of 1: 200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
