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Anti-PMP52 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Novel acetylcholine receptor chaperone |
Synonyms: | Transmembrane protein 35A, PMP52, Tmem35a, NachoPeroxisomal membrane protein 52 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PMP52 |
Uniprot ID: | Q9D328 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 19 kDa / 18 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 800 | brain, stomach |
Background
Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain. Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors. Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function. Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly.
Images
| Western blot analysis of TMEM35 (GB114864) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
