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Anti-PPP4R2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PPP4R2 rabbit polyclonal antibody |
Gene Name: | Serine/threonine-protein phosphatase 4 regulatory subunit 2 |
Synonyms: | Ppp4r2, PP4R2, protein phosphatase 4, regulatory subunit 2 |
Immunogen: | Recombinant protein corresponding to Mouse PPP4R2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q0VGB7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 1000-1: 4000 | pancreas, testis |
Background
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair.
Images
| Immunohistochemistry of paraffin embedded mouse testis using PP4R2 (GB112172) at dilution of 1:2000 (400x lens) |
| Immunohistochemistry of paraffin embedded rat testis using PP4R2 (GB112172) at dilution of 1:2000 (320x lens) |
| Immunofluorescence of paraffin embedded mouse testis using PP4R2 (GB112172) at dilution of 1:1000 (280x lens) |
 | Immunofluorescence of paraffin embedded mouse pancreas using PP4R2 (GB112172) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
