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Anti-Proteasome 19S S4/PSMC1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | 26S proteasome regulatory subunit 4 |
Synonyms: | P26S4, p56, PSMC1, S4 |
Immunogen: | Recombinant protein corresponding to Mouse PSMC1 |
Uniprot ID: | P62192 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 49 kDa / 60 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | heart, kidney |
Background
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Images
| Western blot analysis of PSMC1 (GB114427) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
