Reactivity: | H,M,R & M,R |
Applications: | WB & IHC/IF |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Full Name: | PTBP1 rabbit polyclonal antibody |
Gene Name: | Polypyrimidine tract-binding protein 1 |
Synonyms: | PTB, Heterogeneous nuclear ribonucleoprotein I, hnRNP I, Ptbp1, Ptb, HNRNPI, HNRPI, PTBP1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PTBP1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Predicted MW. | 56 kDa |
Observed MW. | 56 kDa |
Uniprot ID: | P26599, P17225, Q00438 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | Jurkat, A549, K562, C2C12, L6 |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | heart, kidney, lung |
Background
Polypyrimidine tract-binding protein (PTBP1), also known as heterogeneous nuclear ribonucleoprotein type I (hnRNP I), is a nuclear protein that binds pre-mRNAs in specific regions of the hnRNA-protein complexes sensitive to micrococcal nuclease. It involves in pre-mRNA splicing and the regulation of alternative splicing events. PTBP1 promotes RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA, and promotes the binding of U2 snRNP to pre-mRNA.
Images
Western blot analysis of PTBP1 (GB111960) at dilution of 1: 500 | |
Immunohistochemistry of paraffin embedded mouse heart using PTBP1 (GB111960) at dilution of 1: 500 (400x lens) | |
Immunohistochemistry of paraffin embedded mouse kidney using PTBP1 (GB111960) at dilution of 1: 500 (400x lens) | |
Immunohistochemistry of paraffin embedded mouse lung using PTBP1 (GB111960) at dilution of 1: 500 (400x lens) | |
Immunohistochemistry of paraffin embedded rat heart using PTBP1 (GB111960) at dilution of 1: 500 (400x lens) | |
Immunohistochemistry of paraffin embedded rat lung using PTBP1 (GB111960) at dilution of 1: 500 (400x lens) |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |