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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PTEN rabbit polyclonal antibody |
Gene Name: | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
Synonyms: | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, phosphatase and tensin homolog, PTENbeta |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PTEN |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | P60484, O08586 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1: 100-1: 800 | brain, gastric cancer, kidney, lung, small intestine, stomach, testis |
Background
The PTEN protein is widely expressed throughout the body. PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the inositol ring in PIP3, resulting in the biphosphate product PIP2 (PtdIns(4,5)P2). This dephosphorylation is important because it results in inhibition of the AKTsignaling pathway.PTEN also has weak protein phosphatase activity, but this activity is also crucial for its role as a tumor suppressor.
Images
 | Immunohistochemistry of paraffin embedded human stomach using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse brain using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lung using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse testis using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat brain using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat kidney using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat lung using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunofluorescence of paraffin embedded human gastric cancer using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse kidney using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse lung using PTEN (GB11169) at dilution of 1:400 (400x lens) |
 | Immunofluorescence of paraffin embedded rat brain using PTEN (GB11169) at dilution of 1:400 (400x lens) |
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Immunofluorescence of paraffin embedded rat small intestine using PTEN (GB11169) at dilution of 1:400 (400x lens) |
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Immunofluorescence of paraffin embedded rat testis using PTEN (GB11169) at dilution of 1:400 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
