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Anti-PTPN12 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PTPN12 rabbit polyclonal antibody |
Gene Name: | Tyrosine-protein phosphatase non-receptor |
Synonyms: | Protein-tyrosine phosphatase P19, Ptpn12, MPTP-PEST, P19-PTP |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse PTPN12 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Predicted MW. | 88 kDa |
Observed MW. | 110 kDa |
Uniprot ID: | Q05209, P35831, G3V7Q4 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 800 | lung, ovary, testis |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 3000 | brain, cerebellum, colon, lung, lung cancer, ovary, testis |
Background
The PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. The PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion. This suggests it has a regulatory role in controlling cell shape and mobility.
Images
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Western blot analysis of PTPN12 (GB111076) at dilution of 1: 500 |
 | Western blot analysis of PTPN12 (GB111076) at dilution of 1: 500 |
 | Immunohistochemistry of paraffin embedded human colon using PTPN12 (GB111076) at dilution of 1: 2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded human lung cancer using PTPN12 (GB111076) at dilution of 1: 2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse brain using PTPN12 (GB111076) at dilution of 1: 1250 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse lung using PTPN12 (GB111076) at dilution of 1: 2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded mouse ovary using PTPN12 (GB111076) at dilution of 1: 1250 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat lung using PTPN12 (GB111076) at dilution of 1: 2500 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat ovary using PTPN12 (GB111076) at dilution of 1: 2500 (400x lens) |
 | Immunofluorescence of paraffin embedded mouse brain using PTPN12 (GB111076) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse cerebellum using PTPN12 (GB111076) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse ovary using PTPN12 (GB111076) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse testis using PTPN12 (GB111076) at dilution of 1: 1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using PTPN12 (GB111076) at dilution of 1: 1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
