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| Reactivity: | M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Peg3 rabbit polyclonal antibody |
Gene Name: | Paternally-expressed gene 3 protein |
Synonyms: | ASF-1, Peg3, Kiaa0287, Pw1, Zn-finger protein Pw1, Pw1, PEG3 protein, paternally expressed 3 |
Immunogen: | Recombinant protein corresponding to Mouse Peg3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q3URU2 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 500-1: 2000 | brain, placenta |
Background
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed. Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
Images
| Immunohistochemistry of paraffin embedded mouse placenta using PEG3 (GB111977) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using PEG3 (GB111977) at dilution of 1:500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat placenta using PEG3 (GB111977) at dilution of 1:700 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
