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Anti-Phospholipase C gamma 1 / PLC-gamma-1 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | PLCγ1 rabbit polyclonal antibody |
Gene Name: | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1 |
Synonyms: | PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1, Phospholipase C gamma 1, PLCγ1 |
Immunogen: | Recombinant protein corresponding to Mouse PLCγ1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 149 kDa |
Observed MW. | 160 kDa |
Uniprot ID: | P19174 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | Jurkat, MCF7, HeLa |
Background
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. This protein catalyzes the formation of inositol 1, 4, 5-trisphosphate and diacylglycerol from phosphatidylinositol 4, 5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1(acidic fibroblast growth factor) -activated tyrosine kinase.
Images
 |
Western blot analysis of PLCγ1 (GB11569) at dilution of 1: 500 |
Storage
| Storage |
Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer |
PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol. |
