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Anti-Polycystin 1/PC1 Rabbit pAb (100 μl)
| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Polycystin 1 rabbit polyclonal antibody |
Gene Name: | Polycystin-1 |
Synonyms: | PC1, Autosomal dominant polycystic kidney disease 1 protein, PKD1, PBP, PKD, PKD1, Polycystin 1 Precursor |
Immunogen: | Recombinant protein corresponding to Mouse Polycystin 1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 463 kDa |
Observed MW. | >460 kDa |
Uniprot ID: | P98161 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | HEK293, NIH/3t3, PC12, HCT116, SW480 |
Background
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. Involved in renal tubulo genesis. Involved in fluid-flow mechano sensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together with PKD2 (By similarity). and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene.
Images
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Western blot analysis of Polycystin-1 (GB111019) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
