Anti-Pyrin Rabbit pAb (100 μl)

Anti-Pyrin Rabbit pAb (100 μl)

Brand: ServiceBio
Cat. #: GB114534-100
Availability: In Stock
$259.00
-+
Reactivity: H,M,R    
Applications: WB    
Host Species: Rabbit    
Clonality: Polyclonal    
Gene Name:

Pyrin

Synonyms:

FMF, Marenostrin, Mediterranean fever, MEF, MEFV, Pyrin, TRIM20

Immunogen:

Recombinant protein corresponding to Mouse Pyrin

Uniprot ID:

Q9JJ26

Isotype:

IgG

Purity:

Affinity purification

Predicted MW. / Observed MW.

86 kDa / 60 kDa




Product Usage Information

WB

Human, Mouse, Rat

1: 300-1: 500

ovary, lung




Background

Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation.




Images

Western blot analysis of MEFV (GB114534) at dilution of 1: 500




Storage

Storage            Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer            PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.


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