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| Reactivity: | M,R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | QKI rabbit polyclonal |
Gene Name: | Protein quaking |
Synonyms: | HKQ, Hqk, HqkI, QK, QK1, QK5, QKI, RNA binding protein HQK, Quaking protein, Quaking homolog |
Immunogen: | Recombinant protein corresponding to Mouse QKI |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 4000-1: 8000 | brain, heart |
Background
QKI belongs to a family of RNA-binding proteins, which have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. It involves in regulation of RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability. Also it required to protect and promote stability of mRNAs such as MBP and CDKN1B. Beside, it acts as a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia.
Images
| Immunohistochemistry analysis of paraffin-embedded mouse brain using QKI (GB113463) at dilution of 1: 8000 |
| Immunohistochemistry analysis of paraffin-embedded rat brain using QKI (GB113463) at dilution of 1: 8000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using QKI (GB113463) at dilution of 1: 8000 |
| Immunohistochemistry analysis of paraffin-embedded mouse heart using QKI (GB113463) at dilution of 1: 8000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
