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| Reactivity: | H,M,R & H,M |
| Applications: | IHC/IF & ICC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RCC2 rabbit polyclonal antibody |
Gene Name: | Protein RCC2 |
Synonyms: | Rcc2, Kiaa1470, RCC1-like protein TD-60, TD-60, Telophase disk protein of 60 kDa, 2610510H01Rik, 2610529N02Rik, AA536646, AA675016, KIAA1470, mKIAA1470 |
Immunogen: | Recombinant protein corresponding to Mouse RCC2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 56 kDa |
Observed MW. | 60 kDa |
Uniprot ID: | Q9P258, Q8BK67 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, cerebral cortex |
Background
RCC2 (regulator of chromosome condensation 2) is a member of the RCC1 family of guanine nucleotide exchange factors. RCC2 has been identified as part of the chromosomal passenger complex (CPC) which coordinates the chromosomal and cytoskeletal events of mitosis. Chromosomal passengers are proteins present in complexes with aurora B, inner centromeric protein (INCENP), survivin, and borealin. RCC2 has been demonstrated to be required for the recruitment of survivin and aurora B and is essential for proper chromosome segregation and the completion of cell cleavage. Loss of RCC2 inhibits spindle assembly, activates the spindle assembly checkpoint, and blocks cells in prometaphase.
Images
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Western blot analysis of RCC2 (GB111530) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
