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| Reactivity: | H,M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Protein Red |
Synonyms: | Cytokine IK, IK factor, Protein RER, Ik, Red, Rer, CSA2, chondrosarcoma associated protein 2, prer protein |
Immunogen: | Recombinant protein corresponding to Mouse RED |
Uniprot ID: | Q9Z1M8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 66 kDa / 75 kDa |
Product Usage Information
WB | Human, Mouse | 1: 500-1: 1000 | colon, brain |
IHC/IF | Mouse, Rat | 1: 200-1: 400 | kidney, testis |
Background
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi.
Images
| Western blot analysis of IK (GB111908) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using IK (GB111908) at dilution of 1: 200 |
| Immunohistochemistry analysis of paraffin embedded rat testis using IK (GB111908) at dilution of 1: 200 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using RED (GB111908) at dilution of 1: 300 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse testis using RED (GB111908) at dilution of 1: 300 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat brain using RED (GB111908) at dilution of 1: 300 |
| Immunofluorescent analysis of paraformaldehyde-fixed rat kidney using RED (GB111908) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
