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Anti-RENT1/hUPF1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RENT1/hUPF1 rabbit polyclonal |
Gene Name: | Regulator of nonsense transcripts 1 |
Synonyms: | ATP dependent helicase RENT1, HUPF1, KIAA0221, NORF1, pNORF1, RENT1, UPF1, Up-frameshift suppressor 1 homolog, Nonsense mRNA reducing factor 1, mUpf1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RENT1/hUPF1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 124 kDa |
Observed MW. | 130kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 1000-1: 2000 | testis |
IHC/IF | Mouse | 1: 1000-1: 2000 | brain, testis |
Background
Up-Frameshift Suppressor 1 Homolog (UPF1) is the central factor in nonsense-mediated mRNA decay (NMD) and is also directly involved in telomere homeostasis, DNA replication, histone mRNA degradation and staufen-mediated mRNA decay . It is a potential modulator of MALAT1 and that UPF1/MALAT1 pathway could be a therapeutic target for gastric cancer . The molecular mass of UPF1 is 123-130 kDa.
Images
| Western blot analysis of hUPF1 (GB113781) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using hUPF1 (GB113781) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse testis using hUPF1 (GB113781) at dilution of 1: 2000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
