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Anti-RNF11 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | RING finger protein 11 |
Synonyms: | CGI 123, ring finger protein 11, RNF11, SID1669 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse RNF11 |
Uniprot ID: | Q9QYK7 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 17 kDa / 30 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | liver |
Background
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Images
| Western blot analysis of RNF11 (GB114878) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
