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Anti-ROCK1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ROCK1 rabbit polyclonal antibody |
Gene Name: | Rho-associated protein kinase 1 |
Synonyms: | Renal carcinoma antigen NY-REN-35, coiled-coil-containing protein kinase 1, Rho-associated, ROCK-I, p160 ROCK-1, p160ROCK, MGC131603, MGC4361, rokalpha |
Immunogen: | KLH conjugated Synthetic peptide corresponding to HumanROCK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 158 kDa |
Observed MW. | 158 kDa |
Uniprot ID: | Q13464, P70335, Q63644 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | spleen, lung |
Background
ROCK1, also named as p160ROCK and NY-REN-35, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. ROCK1 phosphorylates and activates DAPK3, which then regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. ROCK1 is required for centromere positioning and centromere-dependent exit from mitosis. It is necessary for apoptotic membrane blebbing. ROCK1 catalyzes the reaction: ATP + a protein = ADP + a phosphoprotein.
Images
| Western blot analysis of Rock1 (GB111691) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
