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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ROCK1 rabbit polyclonal |
Gene Name: | Rho-associated protein kinase 1 |
Synonyms: | P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1, Rock1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse ROCK1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Golgi apparatus membrane, Cytoplasm, Cell projection |
Uniprot ID: | P70335, Q63644 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 100-1: 400 | spleen, kidney |
IF | Mouse, Rat | 1: 100-1: 400 | spleen, kidney |
Background
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation.Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.
Images
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Immunohistochemistry analysis of paraffin-embedded rat kidney using ROCK1 (GB11265) at dilution of 1: 300 |
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Immunohistochemistry analysis of paraffin-embedded rat spleen using ROCK1(GB11265) at dilution of 1: 300 |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using ROCK1 (GB11265) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
