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Anti-RPL23 Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RPL23 rabbit polyclonal |
Gene Name: | 60S ribosomal protein L23 |
Synonyms: | 60S ribosomal protein L17, ribosomal protein L23, rpL17, RPL23, L23 |
Immunogen: | Recombinant protein corresponding to Mouse RPL23 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Rat | 1: 400-1: 800 | colon, rectum |
Background
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins . RPL23 is a component of the 60 S large ribosomal subunit that interacts functionally with murine double minute 2 protein (MDM2 or HDM2 in humans). Upon binding to MDM2, RPL23 inhibits MDM2-mediated p53 degradation, thus activating p53 and inducing cellular apoptosis . Intriguingly, RPL23 has also been suggested to be a negative regulator of apoptosis by suppressing the Miz1-induced transcription of the cell cycle inhibitors p15INK4B and p21CIP1.
Images
| Immunohistochemistry analysis of paraffin-embedded rat colon using RPL23 (GB113184) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin-embedded rat rectum using RPL23 (GB113184) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
