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Anti-RRAGB Rabbit pAb (100 μl)
| Reactivity: | H,M,R & M,R |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RRAGB rabbit polyclonal |
Gene Name: | Ras-related GTP-binding protein B |
Synonyms: | RagB, Rragb |
Immunogen: | Recombinant protein corresponding to Mouse RRAGB |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Lysosome |
Predicted MW. | 43 kDa |
Observed MW. | 43 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, testis, heart |
IHC | Mouse, Rat | 1: 2000-1: 4000 | colon, striatum |
Background
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.
Images
| Western blot analysis of RRAGB (GB113042) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded mouse colon using RRAGB (GB113042) at dilution of 1: 4000 |
| Immunohistochemistry analysis of paraffin-embedded mouse striatum using RRAGB (GB113042) at dilution of 1: 4000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
