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Anti-RUNX1 / AML1 Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | RUNX1 rabbit polyclonal |
| Gene Name: | Runt-related transcription factor 1 |
Synonyms: | Runx1, RUNX1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt related transcription factor 1 |
| Immunogen: | Recombinant protein corresponding to Mouse RUNX1 |
| Isotype: | IgG |
| Purity: | Affinity purification |
| Subcellular location: | Nucleus, Cytoplasm(β subunit ) |
| Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1:200-1:1000 | spleen, lymph gland, placente |
IF | Mouse, Rat | 1:250-1:500 | spleen, lymph gland, placente |
Background
Runt-related transcription factor 1 (RUNX1) is a transcription factor that regulates the differentiation of hematopoietic stem cells into mature blood cells. In addition it plays a major role in the development of the neurons that transmit pain. It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). RUNX proteins form a heterodimeric complex with CBFβwhich confers increased DNA binding and stability to the complex. Chromosomal translocations involving the RUNX1 gene are associated with several types of leukemia including M2AML. Mutations in RUNX1 are implicated in cases of breast cancer.
Images
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Immunohistochemistry analysis of paraffin-embedded rat spleen using RUNX1 (GB11797) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded rat lymph gland using RUNX1 (GB11797) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded mouse placenta using RUNX1 (GB11797) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
