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Anti-S100 alpha 6/PRA Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | S100A6 rabbit polyclonal |
Gene Name: | Protein S100-A6 |
Synonyms: | 5B10, Calcyclin, Prolactin receptor-associated protein, S100 calcium-binding protein A6, S100a6, Cacy |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse S100A6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human, Mouse, Rat | 1: 1000-1: 2000 | colon, testis, skin |
IF | Human, Mouse, Rat | 1: 800-1: 2000 | colon cancer, small intestine, lung, testis, skin |
Background
Calcyclin, also known as Protein S100-A6, growth factor-inducible protein 2A9, S-100 calcium-binding protein A6 (S-100A6) or MLN 4, is a homodimeric member of the S-100 calcium-binding protein family whose expression is upregulated in proliferating and differentiating cells. It may function as calcium sensor and modulator, contributing to cellular calcium signaling.Calcyclin is inducible by growth factors and over expressed in acute myeloid leukemias. It is expressed in a cell-specific manner in subpopulations of neurons and astrocytes and in epithelial cells and fibroblasts. Calcyclin is a specific target of S-100B protein in vivo. The binding of Calcyclin to S-100B is stabilized by S-100B-bound calcium and zinc. Calcyclin associates with both Annexin XI and CacyBP (calcyclin-binding protein). It functions to activate several processes along the calcium signal transduction pathway including the regulation of cell growth, proliferation, secretion and exocytosis.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse testis using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat testis using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded mouse skin using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded rat skin using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded human colon cancer using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded mouse small intestine using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded rat lung using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded rat testis using S100A6 (GB111078) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded mouse skin using S100A6 (GB111078) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
