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Anti-S100A9 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | S100A9 rabbit polyclonal |
Gene Name: | Protein S100-A9 |
Synonyms: | Calgranulin-B, Calprotectin L1H subunit, Leukocyte L1 complex heavy chainMRP-14, p14, S100 calcium-binding protein A9, S100A9, CAGB, CFAG, MRP14 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human S100A9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 1000-1: 2000 | colon, colon cancer |
IF | Human | 1: 500-1: 1000 | colon, colon cancer |
Background
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using S100A9 (GB111079) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human colon cancer using S100A9 (GB111079) at dilution of 1: 2000 |
| Immunofluorescence of paraffin embedded human tonsil using S100A9 (GB111079) at dilution of 1: 1000 |
| Immunofluorescence of paraffin embedded human esophagus cancer using S100A9 (GB111079) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
